Immunotherapy is a novel cancer treatment in recent years that utilizes antibodies to block immune checkpoint proteins (also known as immune checkpoint blockade, ICB). It has been proven to enhance the survival rates of cancer patients. Although ICB has shown the ability to restore anti-tumor immune responses by regulating T cells, it is only effective for some cancer patients. Therefore, understanding how tumors evade immune responses is crucial to improving the effectiveness of ICB. Recent studies suggest that a low level of T cell infiltration in the tumor microenvironment (cold tumor) may be one of the factors that reduce the efficacy of ICB treatment. Thus, transforming the microenvironment of cold tumors into hot tumors is a key factor in restoring the effectiveness of ICB treatment. Additionally, recent research indicates that histone deacetylation (HDAC) plays a significant role in cold tumors. Administering epigenetic drugs (such as HDAC inhibitors) can convert tumors from cold tumors to highly T cell-infiltrated tumor microenvironments, thereby enhancing the effectiveness of ICB against cancer. This project aims to recruit outstanding young scholars (both undergraduates or postgraduates) to Taiwan for short-term internships to participate in research.