Multiple drug resistance (MDR) is a major issue to attenuate the effectiveness of chemotherapy to many human malignancies. There is an urgent need to develop a novel therapeutic strategy for the cancer patient with MDR. Our laboratory publications demonstrated that abnormal upregulation of Wnt5A signaling pathway was shown to contribute to regulating the drug-resistance in the MDR cell lines, In addition, the expression level of HGF and its downstream genes and HGF receptor (c-MET) were upregulated in two multidrug-resistant cancer cell lines. Together, those data suggested that VEGF/VEGFR and HGF/c-MET signaling plays an important role in MDR cancer cells. The main objectives of this study is to test whether targeting c-MET/VEGFR2 as a therapeutic approach to treatment of multidrug-resistance cancer cells. Joining our program offers students the opportunity to gain hands-on experience in Laboratory with basic experiments essential for characterizing stem cells. This includes learning stem cell culture, conducting classical western blotting, flow cytometry, fluorescence microscopy, and animal model.

schedule or duration (e.g., a minimum duration of 2 months)