My research focuses on the neuromuscular system, particularly the interactions between motor neurons, Schwann cells, and skeletal muscle in health and disease. Using advanced 3D cell culture platforms and animal models, my work aims to understand the mechanisms underlying neuromuscular dysfunction and to identify potential therapeutic strategies. One major research direction investigates sarcopenia, the age-related loss of skeletal muscle mass and function. In this project, we study how changes in the neuromuscular unit contribute to muscle degeneration, using 3D motor unit models and mouse models to explore cellular communication, neuromuscular junction integrity, and potential interventions to preserve muscle function during aging. Another ongoing project focuses on paclitaxel (PTX)-induced neuromuscular toxicity, which is a common side effect of chemotherapy. We examine how PTX affects neuromuscular junction structure, motor neuron–muscle communication, and muscle physiology. Through behavioral analysis, molecular studies, and imaging of neuromuscular junctions, this research aims to clarify the mechanisms of PTX-induced dysfunction and identify strategies to mitigate chemotherapy-related neuromuscular damage. Together, these studies aim to advance our understanding of neuromuscular pathology and regenerative strategies, with the long-term goal of improving treatments for aging-related muscle loss and chemotherapy-induced neuromuscular disorders.