Welcome to the Labratory of Cellular Signaling and Molecular Imaging (CSMI) in the Department of Biomedical Engineering at National Cheng Kung University. Prof. Wen-Tai Chiu is the PI of CSMI Lab. Prof. Chiu has been engaged in Ca2+-related research for many years, including the regulation of Ca2+ on focal adhesion dynamics, carcinogenesis and chemoresistance. Our lab has also combined engineering technology to construct an optogenetic platform, which can accurately create different Ca2+ oscillations in time and space scales different from traditional chemical stimulation. In addition, we are proficient in various molecular optical imaging, which can reveal the dynamics and changes of various molecules and ions in living cells. National Cheng Kung University has the best Bioimaging Core Facility in Taiwan, which is affiliated with the National Core Facility for Biopharmaceuticals of the National Science and Technology Council. PI (Prof. Wen-Tai Chiu) is the leader of this core facility. Therefore, we are skilled in many advanced equipment and technology for molecular imaging. Ion and molecular imaging, live-cell imaging, Ca2+ signal regulation, epithelial-to-mesenchymal transition, cell death analysis and cancer metastasis in small animals are major skills in the CSMI Lab. Four major research topics are currently conducting in our lab: 1. Effects of the Bcl-2 pore-forming domain on Ca2+ signaling and cell death. 2. Effect of cooking oil fuel components on lung cancer carcinogenesis. 3. Hypoxia induced ERO1A activation in regulation of TNBC metastasis. 4. The molecular mechanism of Ca2+ signaling in regulating autophagy formation. Students admitted for internships will receive a Ministry of Education TEEP scholarship of NT$15,000 to NT$20,000 per month. The internship period is at least two months, and assistance will be provided in applying for student accommodation at National Cheng Kung University. Students from basic medical or life science fields are especially preferred.