Research Field Marine Invertebrates – Secondary metabolites from zoanthids,  tunicates, soft corals, and sponges Marine Microorganisms – Antibiotics from actinobacteria and natural products from mangrove-derived endophytic fungi Medicinal Plants  – Secondary metabolites from Traditional Chinese Medicines and Southeast Asia crude drugs Marine organisms are an essential source of bioactive natural products. With the advancement of marine technology, we can use remotely operated vehicles (ROVs) to conduct research from the photic zone (0-30 meters) into the mesophotic zone (30-150 meters) and obtain mesophotic microorganisms. Now, we are establishing a“mesophotic microorganisms’ library” and screening its extracts with high-throughput screening (HTS). Finally, research topics should be found for developing new anti-cancer or neuroprotective drugs in the future. At present, more than 500 fungi have been isolated and screened. We are using LC-MS data and the Global Natural Products Society Molecular Network (GNPS) analysis to identify the methanolic fraction of the bioactive strains, compounds such as alkaloids, chromones, polyketides, and many unknown marine natural products will be discovered. Because there is scarce natural product research on mesophotic microorganisms, and the bioassays and mass analysis demonstrated positive results, these strains will be selected for marine natural products research. In our continuous research, we will collect and establish a library of mesophotic microorganisms and develop medical applications of mesospheric microbes. The natural product investigation will utilize bio-guided fractionation as the primary strategy, supplemented by HPLC fingerprint profile and LCMS de-replication analysis, to speed up the identification of bioactive ingredients. Moreover, the OSMAC approach will be applied to the fungus that may produce bioactive metabolites to improve their structure diversity. Finally, collaborate with pharmacological researchers to conduct mechanism research and develop new lead drugs.