Our laboratory focuses on the study of the interplay between mitochondria, redox state, and metabolism, and its impact on human
health and disease progression. Our previous studies have shown that oxidative stress promotes replication of enterovirus in host cells, and
causes more severe cell damage. Virus infection can also induce oxidative stress. This forms a positive feedback loop of enteroviral
infection and oxidative stress. We found that enterovirus induces mitochondrial dysfunction in host cells to generate a large amount of
reactive oxygen species. This alters the redox state and metabolism of host cells, changing their susceptibility to viral infection. We are now
studying the underlying molecular mechanisms. Additionally, the disturbances of redox and metabolic homeostasis play pathogenic
processes of degenerative diseases, such as type II diabetes. In recent years, we have also developed a number of technologies related to
metabolomics and mitochondrial research, which are used to study redox metabolism and mitochondrial dysfunction, healthy aging, and related degenerative diseases. Moreover, we are also developing novel nucleic acid detection methods.